Mimestream is the Mac email app all Gmail users should use.
I’m an inveterate email app switcher — I probably cycle through a different app once a week. But I almost always end up back on Mimestream because it feels like Apple’s own Mail app, but with much better support for Gmail features and keyboard shortcuts.
Kevin Purdy at Ars Technica agrees — he published a guide to Gmail-supporting Mac apps and ranks Mimestream number one. You can read about the others but I’ll just save you time — Mimestream is where it’s at.